d-Amphetamine- and SKF38393-induced transient increase in rat striatal dopamine.
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چکیده
منابع مشابه
Individual differences in schizotypal personality traits correlate with amphetamine induced dopamine release in striatal and extra-striatal brain regions
Objective—Schizotypal personality traits are associated with schizophrenia spectrum disorders. Individuals with schizophrenia spectrum disorders demonstrate increased dopamine transmission in the striatum. We sought to determine if individual differences in normal variation in schizotypal traits correlate with dopamine transmission in the striatum and extra-striatal brain regions. Method—63 hea...
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The stimulant drug amphetamine is postulated to enhance dopamine release through the plasmalemmal dopamine transporter by an exchange diffusion with synaptosomal dopamine. Because protein kinase C has been shown to have an effect on dopamine transporter activity, we examined the effect of protein kinase C inhibitors on endogenous dopamine release stimulated by amphetamine in perfused rat striat...
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BACKGROUND Recent brain imaging studies have indicated that schizophrenia is associated with increased amphetamine-induced dopamine release in the striatum. It has long been hypothesized that dysregulation of subcortical dopamine systems in schizophrenia might result from a failure of the prefrontal cortex (PFC) to adequately control subcortical dopaminergic function. The activity of midbrain d...
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Based upon the observation that estrogen acts in the striatum to rapidly modulate dopamine (DA) neural transmission and DA-mediated behaviors, it has been postulated that these effects of estrogen are mediated by a specific, membrane-bound receptor mechanism. To further characterize the pharmacological specificity of the estrogen binding site, the present experiments examine effects of various ...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1999
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)34220-9